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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Trends Biochem Sci. 2021 Jun 18;46(10):832–847. doi: 10.1016/j.tibs.2021.05.007

Figure 1. Lamins’ localization to the nuclear periphery and functional domains.

Figure 1.

(A) The human lamins, lamin A/C (blue), lamin B1 (green), and lamin B2 (yellow), assemble into a network at the inner nuclear periphery where they serve to maintain nuclear shape and interact with both euchromatic and heterochromatic regions of DNA. (B) Lamins have three domains: a head domain, a coiled-coil rod domain (composed of four sub-domains) that mediates interactions with other lamina proteins, and an Ig-like fold domain that mediates interactions with non-lamina proteins.