Table 2.
Parameters describing glucose variability in participants being treated with combination therapy or IDegLira.
| IDeg+DPP-4i | IDegLira | P value | |
|---|---|---|---|
| MAGE (mg/dL) | 74.9 (60.3, 97.7) | 64.8 (52.0, 78.2) | <0.05† |
| M value (mg/dL) | 1975.2 ± 457.0 | 1748.9 ± 364.8 | <0.01 |
| MAG (mg/dL) | 26.1 ± 8.1 | 22.1 ± 6.7 | <0.01 |
| MODD (mg/dL) | 19.9 ± 7.0 | 15.0 ± 4.4 | <0.05 |
| ADRR (mg/dL) | 431.5 ± 70.1 | 404.8 ± 61.2 | <0.05 |
| J-index | 6776.9 (5553.8, 10510.1) | 4984.3 (4412.7, 8123.0) | <0.01† |
| CONGA (mg/dL) | 108.7 ± 26.6 | 96.2 ± 19.6 | <0.01 |
| HBGI | 311.9 ± 47.6 | 288.7 ± 39.3 | <0.01 |
| 24 h mean glucose (mg/dL) | 122.3 ± 28.9 | 108.4 ± 21.5 | <0.01 |
| CV (%) | 24.6 ± 7.7 | 29.3 ± 22.4 | 0.54 |
| SD (mg/dL) | 28.2 (18.8, 36.6) | 21.9 (18.0, 23.7) | <0.05† |
| TBR (%) | 0.5 (0, 1.4) | 2.6 (0, 5.5) | <0.05† |
| TIR (%) | 94.3 (69.0, 99.0) | 94.5 (85.4, 97.4) | 0.56† |
| TAR (%) | 2.3 (0, 20.8) | 0 (0, 5.2) | <0.05† |
Values are expressed as mean ± SD or median (interquartile range). P value of IDeg+DPP-4i vs. IDegLira. †Wilcoxon signed-rank test was applied to the factors: MAGE, J-index, SD, TBR, TIR, and TAR. MAGE: mean amplitude of glycemic excursions; MAG: mean absolute glucose; MODD: mean of daily difference; ADRR: average daily risk range; CONGA: continuous overall net glycemic action; HGBI: high blood glucose index; CV: coefficient of variation; SD: standard deviation; TBR: time below target glucose range; TIR: the target glucose range; TAR: time above target glucose range.