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. Author manuscript; available in PMC: 2022 Apr 15.
Published in final edited form as: Clin Cancer Res. 2021 Jun 10;27(20):5660–5668. doi: 10.1158/1078-0432.CCR-21-0732

Table 4.

Adjusted Estimate of Relative Change in Breast MRI Water and Fat Volume from Baseline at 6 and 12 months in Sulindac and Observation Control.

Group n Change % Water Volume1 (95% CI) P-value Change % Fat Volume2 (95% CI) P- value
AI Only
0 v 6 39 −0.2 (−5.4, 5.3) 0.945 −2.6 (−7.2, 2.2) 0.277
0 v 12 39 −3.7 (−9.8, 2.8) 0.255 1.0 (−5.1, 7.4) 0.755
Sulindac plus AI
0 v 6 44 −4.6 (−9.5, 0.4) 0.072 0.5 (−4.0, 5.3) 0.820
0 v 12 43 −7.6 (−13.3, −1.5) 0.016 5.8 (−0.4, 12.3) 0.067
1

Pooled estimates using all participant data (n=96) adjusted for log-transformed baseline water volume, time on aromatase inhibitor, BMI at each time point on study and study site.

2

Pooled estimates using all participant data (n=96) adjusted for log-transformed baseline fat volume, time on aromatase inhibitor, BMI at each time point on study and study site.