Table 1.
Evolution of plasma lipid profile in high-fat diet-fed obesity-prone and in normal chow-fed obesity-resistant rats during 4 and 12 months.
| 4 months | 12 months | p 4- vs. 12-month high fat diet in OP rats | |||||
|---|---|---|---|---|---|---|---|
| Normal chow in OR rats (n = 8) |
High fat diet
in OP rats (n = 10) |
p |
Normal chow
in OR rats (n = 8) |
High fat diet in OP rats (n = 14) | p | ||
| Triglycerides (in mg.dL−1) |
90 ± 9 | 218 ± 27 | *** | 131 ± 16 | 910 ± 136 | *** | ††† |
| Total cholesterol (in mg.dL−1) |
55 ± 2 | 109 ± 9 | * | 73 ± 4 | 214 ± 22 | *** | ††† |
| HDL-cholesterol (in mg.dL−1) |
44 ± 1 | 66 ± 5 | ** | 54 ± 2 | 86 ± 6 | *** | †† |
| LDL-cholesterol (in mg.dL−1) |
10 ± 1 | 43 ± 7 | *** | 19 ± 2 | 128 ± 19 | *** | ††† |
| LDL/HDL ratio |
0.23 ± 0.02 | 0.69 ± 0.14 | * | 0.35 ± 0.03 | 1.55 ± 0.20 | *** | ††† |
Values are expressed as means ± SEM. *0.01 < p < 0.05, **0.001 < p < 0.01, ***p < 0.001, high-fat diet-fed in obesity-prone (OP) vs. normal chow-fed in obesity-resistant (OR) rats. ††0.001 < p < 0.01, †††p < 0.001, 12- vs. 4-month high-fat diet-fed in obesity-prone (OP) rats. HDL means high-density lipoprotein; LDL, low-density lipoprotein; OR, obesity-resistant rats; OP, obesity-prone rats.