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. 2022 Jan 13;9:806850. doi: 10.3389/fcell.2021.806850

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Copyright © 2022 Liu, Qi, Tian, Yang, Liu, Wang, Ji, Yu, Zeng, Li, Wei and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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USP25 exacerbates acute pancreatitis by destroying tight junctions of the pancreas and STAT3 activation may be involved in vitro and in vivo. (A) Western blotting was used to measure the protein levels of USP25, STAT3, p-STAT3Y705 and ZO-1 protein in AR42J, MPAC cells transferred with nontargeting SiRNAs (NC) or USP25 SiRNA and induced AP with cerulein. (B) Western blotting was performed to measure the protein levels of USP25, STAT3, p-STAT3Y705, and ZO-1 in mice pancreases of the following four groups: USP25WT + NS, USP25WT + cerulein, USP25^−/− + NS, USP25^−/− + cerulein (C) The expression level of p-STAT3Y705 were examined by immunofluorescence in MPAC of two groups: USP25WT + cerulein and USP25^−/− + cerulein (D) ZO-1 were examined by immunofluorescence in mice pancreases of four groups: USP25WT + NS, USP25WT + cerulein, USP25^−/− + NS, USP25^−/− + cerulein mice.