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. 2022 Jan 13;9:806850. doi: 10.3389/fcell.2021.806850

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Copyright © 2022 Liu, Qi, Tian, Yang, Liu, Wang, Ji, Yu, Zeng, Li, Wei and Dong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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USP25 aggravates acute pancreatitis-related liver, kidney, and small intestine injury through activating STAT3 pathway in vivo. Stattic was used to interfere with STAT3 phosphorylation in USP25^WT and USP25^−/−mice, then cerulein was used to induce AP in mice. (A) H&E staining of liver, kidney and small intestine in eight experimental groups (Black arrow: necrosis; red arrow: inflammatory cell; green arrow: cytoplasmic vacuolation; grey arrow: edema; blue arrow: detachment of tubular epithelial cell). (B–D) The histological scores of liver, kidney and small intestine in eight experimental groups. **P<0.01, ***p<0.001 and ****p<0.0001.