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. 2022 Jan 13;8:802998. doi: 10.3389/fcvm.2021.802998

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Copyright © 2022 van der Voorn, Bourfiss, te Riele, Taha, Vos, de Brouwer, Verstraelen, de Boer, Remme and van Veen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fibrosis biomarkers correlated weakly to moderatly to structural/functional parameters. (A) PICP/ICTP ratio was not different in patients with LV LGE (n = 9) compared to patients who did not have LV LGE (n = 14). (B) Only one patient had LGE in the RV, therfore no comparison could be made. (C) A weak negative correlation was found with LVEF (n = 23). (D) No correlation was found with RVEF and fibrosis biomarkers (n = 21). (E,F) Moderate positive correlations were found with LV EDV and ESV (n = 23). (G,H) Weak positive correlations were found with RV EDV and ESV (n = 21). LGE, late gadolinium enhancement; LVEF, left ventricular ejection fraction; RVEF, right ventricular ejection fraction; EDV, end-diastolic volume; ESV, end-systolic volume; PICP, procollagen type I carboxy-terminal pro-peptide; ICTP, C-terminal telopeptide collagen type I; rs, Spearman's rho; ns, not significant.