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. 2022 Jan 13;8:802998. doi: 10.3389/fcvm.2021.802998

Figure 3.

Figure 3

Subpoulation analysis of electrical parameters. (A) A weak positive correlation was found with QRS duration in preclinical pathogenic variant carriers (n = 37). (B) A moderate positive correlation was found with QRS duration in patients diagnosed with ACM (n = 10), while a moderate negative correlation was found with QRS duration in DCM diagnosed patients (n = 11). (C) A significant higher PICP/ICTP ratio was found in preclinical variant carriers that presented with low QRS voltages. (D) No significant difference was found in ACM or DCM diagnosed PLN patients with total collagen turnover and the presence of low QRS voltages. (E) A significant higher PICP/ICTP ratio was found when PVCs were detected during an exericse tolerance test in preclinical variant carriers. (F) No signficant difference was found in PICP/ICTP ratios and the detection of PVCs in ACM or DCM classified PLN patients. Of note, all DCM patients presented with PVCs during an exericse tolerance test (n = 7). ACM, arrhythmogenic cardiomyopathy; DCM, dilated cardiomyopathy; PVCs, premature ventricular contractions; PICP, procollagen type I carboxy-terminal pro-peptide; ICTP, C-terminal telopeptide collagen type I; rs, Spearmann's rho. *p < 0.05.