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. 2022 Jan 13;9:785979. doi: 10.3389/fcell.2021.785979

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Copyright © 2022 Joechle, Jumaa, Thriene, Hellerbrand, Kulemann, Fichtner-Feigl, Lang and Guenzle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MTOR1/2 blockade inhibits migration capacity dose-dependently. Migration capacity of HuCCA1 (A) and HuCCT1 (B) was investigated after exposure of 100–500 nM OSI-027 by wound closure assay over 120 h and displayed as distance of the migration gap. Treated cells were normalized to T0 (start of the experiment) set to 100% (±SD of three independent experiments). Asterisks (* p ≤ 0.05) indicate significance between treatment and the control. Representative images (C) show the initial gap (T0) and the gap after 96 h as well as 120 h of control and treatment of HUCCA1 with 100–500 nM OSI-027. The initial width of the migration gap was 2 mm and is shown as the distance of the migration gap. Scale bar indicates 500 µm.