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. 2022 Jan 13;12:754406. doi: 10.3389/fendo.2021.754406

Table 2.

Association of maternal pre-pregnancy obesity and GAGM and adverse maternal outcomes.

Variables Normal Obese alone GAGM alone Obese with GAGM p value
PIH, n (%) 34 (1.9) 21 (8.2) 25 (4.1) 30 (15.8)
Unadjusted OR (95% CI) 1 (ref) 4.478 (2.556–7.845)* 2.173 (1.285–3.673)* 9.436 (5.627–15.823) <0.001
Adjusted OR (95% CI) 1 (ref) 4.045 (2.286–7.156)* 1.993 (1.171–3.393)* 8.495 (4.982–14.485) <0.001
Preeclampsia, n (%) 23 (1.3) 10 (3.9) 18 (3) 12 (6.3)
Unadjusted OR (95% CI) 1 (ref) 3.031 (1.426–6.445) 2.300 (1.232–4.292)* 5.047 (2.470–10.316) <0.001
Adjusted OR (95% CI) 1 (ref) 2.649 (1.224–5.735) 2.129 (1.128–4.017)* 4.643 (2.217–9.727) <0.001
CS, n (%) 634 (36.3) 125 (48.6) 274 (45.4) 121 (63.7)
Unadjusted OR (95% CI) 1 (ref) 1.659 (1.275–2.159)* 1.455 (1.206–1.755)* 3.073 (2.251–4.195) <0.001
Adjusted OR (95% CI) 1 (ref) 1.589 (1.212–2.083)* 1.328 (1.095–1.611)* 2.627 (1.908–3.617) <0.001
Preterm delivery, n (%) 93 (5.3) 27 (10.5) 44 (7.3) 25 (13.2)
Unadjusted OR (95% CI) 1 (ref) 2.085 (1.329–3.271) 1.396 (0.963–2.023)* 2.691 (1.683–4.305) <0.001
Adjusted OR a (95% CI) 1 (ref) 1.899 (1.205–2.993) 1.358 (0.937–1.968)* 2.301 (1.423–3.720) 0.001
Postpartum hemorrhage, n (%) 38 (2.2) 7 (2.7) 10 (1.6) 6 (3.0)
Unadjusted OR (95% CI) 1 (ref) 1.258 (0.556–2.847) 0.756 (0.374–1.527) 1.465 (0.611–3.512) 0.582
Adjusted OR (95% CI) 1 (ref) 1.254 (0.552–2.848) 0.739 (0.364–1.500) 1.405 (0.579–3.412) 0.591
Placenta previa, n (%) 22 (1.3) 4 (1.6) 11 (1.8) 6 (3.2)
Unadjusted OR (95% CI) 1 (ref) 1.238 (0.423–3.623) 1.453 (0.700–3.014) 2.554 (1.022–6.379) 0.233
Adjusted OR (95% CI) 1 (ref) 0.938 (0.314–2.799) 1.231 (0.586–2.589) 1.877 (0.731–4.819) 0.590
Placenta abruption, n (%) 2 (0.1) 1 (0.4) 0 (0) 0 (0)
Unadjusted OR (95% CI) 1 (ref) 3.404 (0.308–37.678) 0.802
Adjusted OR (95% CI) 1 (ref) 3.199 (0.277–36.965) 0.833
Dystocia, n (%) 39 (2.2) 2 (0.8) 11 (1.8) 4 (2.1)
Unadjusted OR (95% CI) 1 (ref) 0.343 (0.082–1.429) 0.811 (0.413–1.595) 0.941 (0.332–2.662) 0.500
Adjusted OR (95% CI) 1 (ref) 0.404 (0.096–1.688) 0.925 (0.467–1.832) 1.248 (0.435–3.586)
Total adverse maternal outcomes, n (%) 741 (42.5) 153 (59.5) 321 (53.1) 140 (73.4)
Unadjusted OR (95% CI) 1 (ref) 1.993 (1.527–2.602)* 1.537 (1.276–1.851)* 3.794 (2.710–5.312) <0.001
Adjusted OR (95% CI) 1 (ref) 1.762 (1.331–2.332)* 1.365 (1.122–1.659)* 3.228 (2.272–4.587) <0.001

Adjusted OR: adjusted for maternal age, gestational age, and primiparity. Adjusted ORa: adjusted for maternal age, and primiparity. *p < 0.05 vs. obese with GAGM.