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. 2022 Jan 13;12:754406. doi: 10.3389/fendo.2021.754406

Table 3.

Association of maternal pre-pregnancy obesity and GAGM and adverse neonatal outcomes.

Variables Normal Obese alone GAGM alone Obese with GAGM p value
Low birth weight, n (%) 53 (3.0) 12 (4.7) 28 (4.6) 15 (7.9)
Unadjusted OR (95% CI) 1 (ref) 1.564 (0.824–2.968) 1.552 (0.972–2.477) 2.736 (1.511–4.956) 0.006
Adjusted OR (95% CI) 1 (ref) 0.999 (0.460–2.169)* 1.429 (0.837–2.438) 2.539 (1.295–4.981) 0.045
Macrosomia, n (%) 80 (4.6) 25 (9.7) 51 (8.4) 33 (17.4)
Unadjusted OR (95% CI) 1 (ref) 2.243 (1.402–3.587)* 1.919 (1.334–2.763)* 4.375 (2.825–6.774) <0.001
Adjusted OR (95% CI) 1 (ref) 2.449 (1.517–3.954)* 1.966 (1.356–2.851)* 4.576 (2.895–7.233) <0.001
Fetal asphyxia, n (%) 17 (1.0) 4 (1.6) 11 (1.8) 5 (2.6)
Unadjusted OR (95% CI) 1 (ref) 1.607 (0.536–4.814) 1.886 (0.878–4.048) 2.747 (1.002–7.532) 0.165
Adjusted OR (95% CI) 1 (ref) 0.808 (0.207–3.147) 1.754 (0.695–4.426) 2.966 (1.303–9.740) 0.230
Fetal distress, n (%) 43 (2.5) 9 (3.5) 9 (1.5) 4 (2.1)
Unadjusted OR (95% CI) 1 (ref) 1.436 (0.692–2.983) 0.599 (0.290–1.236) 0.851 (0.302–2.398) 0.320
Adjusted OR (95% CI) 1 (ref) 1.633 (0.781–3.413) 0.666 (0.321–1.382) 1.069 (0.375–3.047) 0.318
Fetal deformities, n (%) 14 (0.8) 6 (2.3) 8(1.3) 1 (0.5)
Unadjusted OR (95% CI) 1 (ref) 0.375 (0.037–3.795) 1.660 (0.693–3.976) 1.660 (0.693–3.976) 0.130
Adjusted OR (95% CI) 1 (ref) 1.835 (0.565–5.964) 1.036 (0.336–3.195) 0.375 (0.037–3.795) 0.570
Stillbirth, n (%) 7 (0.4) 3 (1.2) 5 (0.8) 2 (1.0)
Unadjusted OR (95% CI) 1 (ref) 2.933 (0.753–11.413) 1.655 (0.483–5.674) 2.641 (0.545–12.806) 0.373
Adjusted OR (95% CI) 1 (ref) 1.489 (0.300–7.390) 1.130 (0.279–4.582) 2.078 (0.348–12.394) 0.860
Total adverse neonatal outcomes, n (%) 182 (10.4) 51 (19.8) 95 (15.7) 56 (29.5)
Unadjusted OR (95% CI) 1 (ref) 2.216 (1.509–2.996)* 1.603 (1.227–2.094)* 3.589 (2.535–5.018) <0.001
Adjusted OR (95% CI) 1 (ref) 1.951 (1.361–2.798)* 1.547 (1.170–2.046)* 3.557 (2.471–5.122) <0.001

Adjusted OR: adjusted for maternal age, gestational age, and primiparity.

*p < 0.05 vs. obese with GAGM.