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. 2022 Jan 13;12:814843. doi: 10.3389/fgene.2021.814843

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Copyright © 2022 Zhu, Zhang, Wang, Zhang, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune status of osteosarcoma clusters. (A) C1 shows the lowest immune and stromal score than the clusters. (B) The ssGSEA and (C) MCP-counter analysis plotted in the form of a hierarchical heat map (C3) show the highest immune score. (D) Highly expressed genes in three clusters. (E) PPI of highly expressed genes showing association with immune function. (F) GO enrichment and (G) KEGG enrichment analysis of the genes associated with immune function.