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. 2022 Jan 13;12:741450. doi: 10.3389/fneur.2021.741450

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Copyright © 2022 Müller, Dekkers, Wiest, Schindler and Rummel.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example display of iEEG signals and corresponding non-linear excess interrelations. Shown are 8 s of preictal iEEG signals (panel 1) with various annotations of epileptiform events (green boxes). The non-linear excess interrelation matrices are shown for the selected 8-s segment (panel 2) and as average over the entire epoch of 180 s duration (panel 3). The core channels of both matrices are indicated by arrows on the respective y-axes and the selected segment's core channel TAR3 is in addition plotted in red in the EEG display. The RBT is indicated by arrows on the x-axes of the matrices and typeset in boldface in the EEG display. The similarity between all segment-wise matrices and their epoch-wise average was measured by the Pearson correlation coefficient between their elements (panel 4). High precision and low recall of the core of the selected segment to predict the RBT are representative for the entire epoch (panel 5).