Table 3.

Subgroup analysis of pooled estimates of BUN.

Subgroup	No. of studies	Sample size	WMD (95% CI)	P-value
Ischemia duration
≤ 45 min	8	65/57	−32.17 [−52.81, −11.53]	0.002
> 45 min	13	105/97	−28.45 [−41.89, −15.01]	< 0.00001
Unilateral or bilateral
Unilateral	13	104/96	−20.49 [−36.03, −4.94]	0.01
Bilateral	8	66/58	−47.06 [−70.78, −23.34]	0.0001
Dosage
< 10 mg/kg	6	44/40	−35.61 [−62.98, −8.23]	0.01
= 10 mg/kg	10	80/68	−38.07 [−70.19, −5.94]	0.02
> 10 mg/kg	6	46/46	−15.25 [−22.76, −7.74]	< 0.0001
Times of administration
Single	10	90/74	−28.92 [−61.27, 3.43]	0.08
Multiple	11	80/80	−26.51 [−36.86, −16.15]	< 0.00001
Administration time
Before ischemia	16	133/117	−27.66 [−42.27, −13.06]	0.0002
After reperfusion	5	37/37	−40.59 [−72.17, −9.01]	< 0.00001
Risk of bias
<4	14	120/104	−24.55 [−38.44, −10.65]	0.0005
≥4	7	50/50	−43.65 [−65.43, −21.69]	< 0.0001

BUN, blood urea nitrogen; WMD, weighted mean difference; CI, confidence interval.