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. Author manuscript; available in PMC: 2022 Jan 27.
Published in final edited form as: Curr Opin Immunol. 2020 Mar 2;63:51–60. doi: 10.1016/j.coi.2020.02.001

Figure 1.

Figure 1

Opposing influences on FOXO1 cellular localization and transcriptional activity. PI3K, Phosphoinositide 3-kinase; PTEN, Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase; PDPK1, 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1); mTORC2, mTOR complex 2 (consisting of 7 components); AKT, (Protein Kinase B); PP2A, Protein phosphatase 2A; HDAC, Histone deacetylase; AMPK, 5′ adenosine monophosphate-activated protein kinase; STK4, Serine/Threonine Kinase 4 (MST1); OGT, O-Linked N-Acetylglucosamine (GlcNAc) Transferase; PRMT1, protein arginine methyltransferase; JNK, Jun N-terminal protein kinase.