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. 2021 Aug 25;6(2):361–373. doi: 10.1002/hep4.1810

FIG. 3.

FIG. 3

PK and excretion of APAP, major APAP metabolites, and APAP‐protein adducts. Parent APAP, APAP‐Gluc, APAP‐Sulf, and APAP‐protein adducts were measured in serial blood samples after the final dose of APAP on day 5 by LC‐MS/MS or HPLC‐EC. (A) Serum APAP. (B) Serum APAP‐Gluc. (C) Serum APAP‐Sulf. (D) Serum APAP‐protein adducts. (E) Fractional urinary excretion of APAP, APAP‐Gluc, and APAP‐Sulf in control subjects without cirrhosis. (F) Fractional urinary excretion of APAP, APAP‐Gluc, and APAP‐Sulf in subjects with cirrhosis. Data are expressed as mean ± standard error for n = 12 per group. PK parameters with P values are displayed in Table 4. Abbreviation: Vol, volunteer.