TABLE 1.
Cohort Characteristics
| Characteristic | Complete Cohort (n = 7,072) | Normal Aminotransferase Levels (n = 4,229) | Liver Disease, No Advanced Fibrosis (n = 1,946) | Liver Disease, Advanced Fibrosis (n = 126) | Liver Disease, Uncharacterized (n = 771) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Prop./Mean | 95% CI | Prop./Mean | 95% CI | Prop./Mean | 95% CI | Prop./Mean | 95% CI | Prop./Mean | 95% CI | |
| Age | 46.1 | [45.3‐46.8] | 45.2 | [44.5‐45.8] | 49.0 | [47.9‐50.2] | 52.0 | [49.7‐54.3] | 43.1 | [41.3‐44.9] |
| Female | 0.501 | [0.491‐0.511] | 0.477 | [0.461‐0.494] | 0.535 | [0.507‐0.563] | 0.291 | [0.202‐0.380] | 0.572 | [0.527‐0.617] |
| Ethnicity | ||||||||||
| White (Non‐Hispanic) | 0.736 | [0.700‐0.773] | 0.746 | [0.707‐0.786] | 0.721 | [0.679‐0.762] | 0.708 | [0.610‐0.806] | 0.724 | [0.677‐0.772] |
| Black (Non‐Hispanic) | 0.0931 | [0.0712‐0.115] | 0.0978 | [0.0743‐0.121] | 0.0914 | [0.0675‐0.115] | 0.113 | [0.0517‐0.175] | 0.0698 | [0.0477‐0.0918] |
| Mexican American | 0.0696 | [0.0514‐0.0878] | 0.0621 | [0.0455‐0.0787] | 0.0760 | [0.0533‐0.0987] | 0.0678 | [0.0313‐0.104] | 0.0954 | [0.0643‐0.126] |
| Other Hispanic | 0.0679 | [0.0342‐0.102] | 0.0648 | [0.0306‐0.0990] | 0.0690 | [0.0366‐0.101] | 0.0760 | [0.00723‐0.145] | 0.0812 | [0.0362‐0.126] |
| Multi‐ethnic | 0.0328 | [0.0223‐0.0433] | 0.0289 | [0.0187‐0.0392] | 0.0430 | [0.0220‐0.0641] | 0.0350 | [0.000‐0.0878] | 0.0293 | [0.0179‐0.0406] |
| BMI | 28.1 | [27.8‐28.4] | 27.1 | [26.8‐27.4] | 30.6 | [30.0‐31.1] | 29.0 | [27.6‐30.5] | 27.5 | [26.9‐28.0] |
| MetS | 0.332 | [0.315‐0.349] | 0.221 | [0.208‐0.233] | 0.712 | [0.677‐0.748] | 0.660 | [0.554‐0.767] | 0.000 | [0.000‐0.000] |
| CVD | 0.0617 | [0.0541‐0.0693] | 0.0608 | [0.0518‐0.0698] | 0.0696 | [0.0568‐0.0823] | 0.104 | [0.0411‐0.166] | 0.0424 | [0.0231‐0.0617] |
| Malignancy | 0.0777 | [0.0680‐0.0874] | 0.0795 | [0.0668‐0.0923] | 0.0779 | [0.0625‐0.0932] | 0.117 | [0.0454‐0.188] | 0.0625 | [0.0395‐0.0855] |
| Obese (BMI) | 0.297 | [0.276‐0.318] | 0.234 | [0.212‐0.256] | 0.463 | [0.428‐0.498] | 0.326 | [0.194‐0.458] | 0.247 | [0.208‐0.286] |
| Obese (waist circumference) | 0.483 | [0.459‐0.507] | 0.391 | [0.364‐0.417] | 0.719 | [0.686‐0.753] | 0.626 | [0.527‐0.724] | 0.406 | [0.357‐0.455] |
| Diabetes | 0.295 | [0.277‐0.314] | 0.232 | [0.216‐0.247] | 0.510 | [0.477‐0.543] | 0.629 | [0.521‐0.737] | 0.0921 | [0.0676‐0.117] |
| Smoking history | 0.504 | [0.478‐0.530] | 0.496 | [0.464‐0.527] | 0.563 | [0.524‐0.602] | 0.666 | [0.564‐0.769] | 0.392 | [0.343‐0.441] |
| Excess alcohol use | 0.227 | [0.214‐0.239] | 0.179 | [0.166‐0.193] | 0.412 | [0.374‐0.450] | 0.581 | [0.488‐0.674] | 0.000 | [0.000‐0.000] |
| TL (kbp) | 5.79 | [5.72‐5.86] | 5.81 | [5.74‐5.88] | 5.75 | [5.67‐5.83] | 5.62 | [5.45‐5.79] | 5.82 | [5.75‐5.90] |
Abbreviations: BMI, body mass index; Prop, proportion.