TABLE 1.
Loci Associated With NAFLD in the UKB Cohort
| RSID | Chr:Pos | Reference Allele/Effect Allele | EAF | OR (95% CI) | P Value | Consequence (Gene) | Hypothesized Functional Gene |
|---|---|---|---|---|---|---|---|
| rs2642442 | 1:220973563 | C/T | 0.317 | 1.15 (1.10‐1.20) | 7.67−10 | Intron (MARC1) | MARC1 |
| rs1260326 | 2:27730940 | T/C | 0.392 | 0.87 (0.84‐0.91) | 2.54−11 | Missense (GCKR) | GCKR |
| rs17321515 | 8:126486409 | A/G | 0.476 | 0.86 (0.82‐0.89) | 1.81−13 | Intergenic (TRIB1) | TRIB1 |
| rs73001065 | 19:19460541 | G/C | 0.071 | 1.41 (1.32‐1.51) | 1.08−24 | Intron (MAU2) | TM6SF2 |
| rs429358 | 19:45411941 | T/C | 0.156 | 0.82 (0.77‐0.87) | 2.17−11 | Missense (APOE) | APOE |
| rs3747207 | 22:44324855 | G/A | 0.215 | 1.45 (1.38‐1.51) | 6.74−60 | Intron (PNPLA3) | PNPLA3 |
Functional role is based on assessment of published literature. Chromosome and position based on Genome Reference Consortium Human Build 37. Effect allele is the minor allele.
Abbreviations: Chr:Pos, chromosome:position; EAF, effect allele frequency; P Value, P value using allelic model.