TABLE 2.
Association of Identified Loci with NAFLD in the Replication Cohort
| RSID | Chr:Pos | Reference Allele/Effect Allele | GS‐SFHS | Namjou et al. | Anstee et al. | Meta‐analysis | Gene | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| EAF | OR (95% CI) | P Value | OR* | P Value | OR (95% CI) | P Value | P Value | ||||
| rs2642442 | 1:220973563 | C/T | 0.311 | 1.06 (0.73‐1.54) | 0.551 | 1.19 | 5.96−03 | 1.16 (1.06‐1.26) | 9.70−04 | 5.83−12 | MARC1 |
| rs1260326 | 2:27730940 | T/C | 0.387 | 0.73 (0.52‐1.03) | 0.00737 | 0.90 | 7.34−02 | 0.78 (0.73‐0.84) | 1.06−10 | 3.08−15 | GCKR |
| rs17321515 | 8:126486409 | A/G | 0.478 | 0.94 (0.67‐1.32) | 0.913 | 0.80 | 1.08−04 | 0.86 (0.79‐0.93) | 1.99−04 | 1.24−16 | TRIB1 |
| rs73001065 | 19:19460541 | G/C | 0.065 | 0.79 (0.37‐1.69) | 0.591 | 1.30 | 1.19−02 | 1.58 (1.37‐1.82) | 1.59−10 | 7.51−30 | TM6SF2 |
| rs429358 | 19:45411941 | T/C | 0.162 | 0.70 (0.41‐1.18) | 0.126 | 0.81 | 9.57−03 | 0.85 (0.77‐0.95) | 4.16−03 | 3.42−13 | APOE |
| rs3747207 | 22:44324855 | G/A | 0.194 | 1.37 (0.92‐2.03) | 0.142 | 1.78 | 2.63−20 | 1.83 (1.68‐1.98) | 2.58−49 | 1.67−87 | PNPLA3 |
Chromosome and position based on Genome Reference Consortium Human Build 37.
*
The summary association statistics for Namjou et al. did not provide a CI or standard error for the odds ratio.
Abbreviations: Chr:Pos, chromosome:position; EAF, effect allele frequency; P Value, P value using allelic model.