TABLE 3.
Fungus (no. of isolates tested) | Antifungal agenta | Incubation time (h) or reading no. | No. of isolates for which MICs determined by E-test differed from MICs determined by method by the following dilution:
|
% Agreementb | ||||||
---|---|---|---|---|---|---|---|---|---|---|
>+2 | >+2 | +1 | 0 | −1 | −2 | >−2 | ||||
A. flavus (16) | A | 24 | 4 | 3 | 3 | 3 | 1 | 2 | 75 | |
48 | 11 | 3 | 1 | 1 | 31.2 | |||||
I | 24 | 3 | 5 | 5 | 3 | 100 | ||||
48 | 7 | 4 | 5 | 100 | ||||||
A. fumigatus (69) | A | 24 | 4 | 14 | 16 | 22 | 8 | 2 | 97 | |
48 | 25 | 15 | 8 | 21 | 63.8 | |||||
I | 24 | 5 | 11 | 17 | 23 | 7 | 2 | 1 | 90 | |
48 | 18 | 12 | 20 | 17 | 2 | 74 | ||||
A. nidulans (12) | A | 24 | 1 | 2 | 2 | 4 | 1 | 1 | 83.3 | |
48 | 5 | 2 | 4 | 1 | 58.3 | |||||
I | 24 | 1 | 2 | 1 | 5 | 2 | 83.3 | |||
48 | 2 | 1 | 1 | 6 | 2 | 83.3 | ||||
A. niger (10) | A | 24 | 2 | 5 | 3 | 100 | ||||
48 | 3 | 7 | 100 | |||||||
I | 24 | 1 | 9 | 100 | ||||||
48 | 1 | 9 | 100 | |||||||
A. terreus (16) | A | 24 | 2 | 1 | 5 | 3 | 1 | 1 | 77 | |
48 | 3 | 4 | 4 | 4 | 1 | 75 | ||||
I | 24 | 1 | 4 | 3 | 1 | 4 | 92 | |||
48 | 2 | 4 | 3 | 2 | 1 | 4 | 88 | |||
F. oxysporum (6) | A | 24 | 5 | 1 | NAc | |||||
48 | 6 | NA | ||||||||
I | 24 | 2 | 3 | 1 | NA | |||||
48 | 6 | NA | ||||||||
F. solani (10) | A | 24 | 1 | 1 | 2 | 2 | 2 | 2 | 70 | |
48 | 6 | 1 | 1 | 2 | 40 | |||||
I | 24 | 10 | 100 | |||||||
48 | 10 | 100 | ||||||||
P. lilacinus (4) | A | 48–72 | 4 | NA | ||||||
I | 48–72 | 1 | 2 | 1 | NA | |||||
S. apiospermum (10) | A | 48 | 3 | 3 | 4 | 100 | ||||
72 | 3 | 3 | 4 | 100 | ||||||
I | 48 | 3 | 4 | 3 | 100 | |||||
72 | 3 | 4 | 3 | 100 | ||||||
S. prolificans (5) | A | 24 | ||||||||
48 | 1 | 4 | NA | |||||||
I | 24 | |||||||||
48 | 1 | 4 | NA | |||||||
T. longibrachiatum (5) | A | 24 | 3 | 2 | NA | |||||
48 | 2 | 3 | NA | |||||||
I | 24 | 5 | NA | |||||||
48 | 5 | NA | ||||||||
Dematiaceous molds (18)d | A | 48 | 1 | 3 | 3 | 5 | 2 | 2 | 93.7 | |
72 | 1 | 3 | 4 | 5 | 93.3 | |||||
I | 48 | 1 | 1 | 3 | 2 | 7 | 7 | 81.2 | ||
72 | 1 | 3 | 7 | 2 | 2 | 2 | 83.3 | |||
All isolates (181) | A | Reading 1 | 14 | 17 | 36 | 42 | 33 | 15 | 6 | 87.7 |
Reading 2 | 57 | 27 | 22 | 40 | 26 | 8 | 1 | 67.9 | ||
I | Reading 1 | 7 | 21 | 29 | 63 | 21 | 17 | 5 | 92.7 | |
Reading 2 | 21 | 26 | 41 | 63 | 15 | 11 | 4 | 86 |
A, amphotericin B; I, itraconazole.
Percent agreement is the percentage of the MIC results obtained by the two methods that were within 3 dilutions.
NA, not applicable (too few isolates).
Isolates of C. bantiana needed 4 days of incubation.