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. Author manuscript; available in PMC: 2022 Jan 27.
Published in final edited form as: Annu Rev Biochem. 2021 Jun 20;90:507–534. doi: 10.1146/annurev-biochem-081720-023244

Figure 4.

Figure 4

Adapting single-cell mechanical stimulation methods to high-throughput formats. (Left) Existing methods for applying mechanical force to the cell membrane. For reference, a graphic depiction of a single PIEZO2 channel is shown in dark orange spanning the cell membrane. (Right) Potential strategies for adapting each method for use in high-throughput screening platforms. Yellow arrows indicate the direction of mechanical force in each assay.