Table 1.

Top enriched metabolites in either SNL+GEG or SNL+SEG vs SNL group

SNL+GEG group vs SNL group*
Metabolite Name	Formula	Log2 Fold Change (SNL+GEG/SNL)	P-value	Adj. P-value
1'-Acetoxyeugenol acetate	C14 H16 O5	13.10	5.52E-05	0.0009558
(4E)-1,7-Bis(4-hydroxyphenyl)-4-hepten-3-one	C19 H20 O3	11.20	2.30E-07	5.86E-05
NP-000629	C14 H16 O4	10.86	1.34E-05	0.00045946
7,8-Dimethoxy-3-(2-methyl-3-buten-2-yl)-2H-chromen-2-one	C16 H18 O4	10.32	1.57E-06	0.00015679
3-{[4-(2-Pyrimidinyl)piperazino]carbonyl}-2-pyrazinecarboxylic acid	C14 H14 N6 O3	10.30	1.60E-07	5.46E-05
920863	C16 H20 O5	10.27	3.01E-07	6.50E-05
(1R,3R,7R,13S)-13-Methyl-6-methylene-4,14,16-trioxatetracyclo[11.2.1.0~1,10~.0~3,7~]hexad ec-9-en-5-one	C15 H18 O4	10.11	5.83E-06	0.00029074
SNL+SEG group vs SNL group*
Metabolite Name	Formula	Log2 Fold Change (SNL+SEG/SNL)	P-value	Adj. P-value
(+/−)-5-[(tert-Butylamino)-2'-hydroxypropoxy]-1_2_3_4-tetrahydro-1-naphthol	C17 H27 N O3	11.57	1.93E-08	7.44E-05
Dehydroepiandrosterone sulfate (DHEAS)	C19 H28 O5 S	10.16	8.99E-07	0.00043157

^*Top metabolites were included if fold change ≥ 10 and adjusted P-value ≤ 0.001