Table 2.
Top enriched and shared metabolites in both SNL+GEG and SNL+SEG groups vs SNL group
| Metabolite Name* | Log2 Fold Change |
Log2 Fold Change |
|---|---|---|
| (SNL+GEG/SNL) | (SNL+SEG/SNL) | |
| (+)-(1R_2R)-1_2-Diphenylethane-1_2-diol | 7.19 | 6.19 |
| [ST(3:0)]estra-1_3_5(10)-triene-2_4_17beta-triol | 8.15 | 6.95 |
| 1-(4-Hydroxy-3-methoxyphenyl)-3-oxo-5-decanesulfonic acid | 6.7 | 8.61 |
| 1-[2-(3-Hydroxy-1-propen-2-yl)-2,3-dihydro-1-benzofuran-5-yl]ethanone | 9.79 | 10.6 |
| 16a-Hydroxyestrone | 6.24 | 6.18 |
| 1'-Acetoxychavicol acetate | 5.35 | 6.55 |
| 1-Hydroxy-4-isopropyl-7-methoxy-1,6-dimethyl-2(1H)-naphthalenone | 7.6 | 7.12 |
| 3,7,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one | 6.81 | 7.67 |
| 3-{[4-(2-Pyrimidinyl)piperazino]carbonyl}-2-pyrazinecarboxylic acid | 10.3 | 8.15 |
| 4,4'-(3,4-Dimethyltetrahydrofuran-2,5-diyl)bis(2-methoxyphenol) | 6.35 | 6.59 |
| 5-[(1E)-3-hydroxy-3-methylbut-1-en-1-yl]-2-methylcyclohex-5-ene-1,2,4-triol | 8.26 | 5.99 |
| 6-{4-Oxo-5-[(2E)-2-penten-1-yl]-2-cyclopenten-1-yl}hexanoic acid | 5.16 | 6.23 |
| 7,8-Dihydroxy-3,7-dimethyl-6-oxo-7,8-dihydro-6H-isochromene-5-carbaldehyde | 7 | 6.64 |
| 8'-Hydroxyabscisate | 6.45 | 8.38 |
| alpha-Santonin | 6.87 | 5.19 |
| Benzylideneacetone | 6.56 | 6.21 |
| Dihydrokavain | 6.03 | 7.52 |
| Di-n-Amyl phthalate | 5.78 | 6.7 |
| Ethyl vanillin isobutyrate | 5.91 | 11.34 |
| Mazindol-d4 | 9.04 | 5.68 |
| Methyl (2E,4E)-5-(3,8-dihydroxy-1,5-dimethyl-6-oxabicyclo[3.2.1]oct-8-yl)-3-methyl-2,4-pentadienoate | 6.91 | 5.35 |
| methyl 2-[4-ethenyl-2,6-dihydroxy-3-(3-hydroxyprop-1-en-2-yl)-4-methylcyclohexyl]prop-2-enoate | 5.49 | 5.17 |
| Methyl N-formylnorleucylleucylphenylalaninate | 8.3 | 8.7 |
| Resorcinol diglycidyl ether | 6.35 | 8.32 |
| Sakuranetin | 8.1 | 5.48 |
| Trepibutone | 8.39 | 6.9 |
| Ubiquinone-1(CoQ1) | 5.31 | 8.36 |
| zinniol | 6.04 | 5.94 |
*
Shared metabolites were included if fold change for both SNL+GEG/SNL and SNL+SEG/SNL ≥ 5 and adjusted P-value ≤ 0.05