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. 2022 Jan 25;60(1):212–224. doi: 10.1080/13880209.2022.2025860

Figure 4.

Figure 4.

Memory deficits in rats after amyloid-β infusion. The amyloid-β(25–35) infused rats were fed high-fat diets containing dextrin (AD-CON group), water extract of Cassiae Semen (AD-CS group), or water extract of Forsythiae Fructus (the AD-FF group) for 49 days. The amyloid-β(35–25) infused rats were fed a high-fat diet containing dextrin (CON group). At the end of the experiment, (A) Amyloid-β deposition in the hippocampus by immunohistochemistry method. (B) The percentage of correct alternations to total rotations in the Y maze test on an experimental day 37 from the amyloid-β infusion. (C) Latency time to enter the darkened room in the passive avoidance test 3 times every 8 h on day 41 from the amyloid-β infusion. (D) The frequencies of visiting the zone where the platform was located, time spent in the zone, and time spent finding the target zone in the third trial on day 43 from the amyloid-β infusion. Dots and error bars represent the means ± standard deviations (n = 4 for brain amyloid-β deposition; n = 10 for memory deficit). *Significantly different from the AD-CON by Tukey test at p < 0.05. †Significantly different from the CON by Tukey test at p < 0.05.