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. 2022 Jan 25;60(1):212–224. doi: 10.1080/13880209.2022.2025860

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Amyloid-β deposition, expression of brain growth factor, neuroinflammation, and insulin signalling in the hippocampus. Amyloid-β_(25–35) infused rats were fed a high-fat diet containing dextrin (AD-CON group), water extract of Cassiae Semen (AD-CS), or water extract of Forsythiae Fructus (AD-FF group) for 49 days. Amyloid-β_(35–25) infused rats were fed a high-fat diet containing dextrin (CON group). Hippocampal insulin signalling (phosphorylation and contents of Akt, GSK-3β, FOXO1, and tau) was measured by immunoblotting. Bars and error bars represent means ± standard deviations (n = 4). *Significantly different from the AD-CON by Tukey test at p < 0.05. ^†Significantly different from the CON by Tukey test at p < 0.05.