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. 2022 Jan 25;60(1):212–224. doi: 10.1080/13880209.2022.2025860

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Gut microbiome profiles. Faeces were collected from the caeca at the end of the experiment, and bacterial DNA was analysed using the NGS method. Amyloid-β_(25–35) infused rats were fed a high-fat diet containing dextrin (AD-CON group), water extract of Cassiae Semen (AD-CS group), or water extract of Forsythiae Fructus (AD-FF group) for 49 days. Amyloid-β_(35–25) infused rats were fed a high-fat diet containing dextrin (CON group). The microbiome of faeces in the caecum was measured by the NGS method at the end of the study. Short-chain fatty acid (SCFA) concentrations in the serum from the portal vein were measured by gas chromatography. (A) Principal coordinate analysis (PCoA) of faecal bacteria. (B) Relative amounts (%) of Bacteriodales, Clostridales, and Erysipelotrichales in faecal samples. (C) Relative amounts (%) of Lactobacillales, Desulfovibrionales, and Enterobacteriales in faecal samples. (D) Serum concentrations of SCFA as determined by gas chromatography. Bars and error bars represent the means ± standard deviations (n = 10). *Significantly different from the AD-CON by Tukey test at p < 0.05. ^†Significantly different from the CON by Tukey test at p < 0.05.