Table 3.

Liver damage and oxidative stress and neuroinflammation in the hippocampus.

Variables	AD-Con	AD-CS	AD-FF	CON
Hippocampal triglyceride (mg/g)	243 ± 9	209 ± 9*	202 ± 8*	210 ± 8*
Hippocampal glycogen (mg/g liver)	39.3 ± 3.5	55.5 ± 6.8*	54.5 ± 6.5*	54.1 ± 5.9*
Hippocampal lipid peroxides (MDA μmol/g tissue)	0.39 ± 0.05	0.26 ± 0.04*†	0.21 ± 0.04*	0.22 ± 0.03*
Relative mRNA expression of hippocampal TNF-α (AU)	1.0 ± 0	0.71 ± 0.09*†	0.66 ± 0.08*†	0.57 ± 0.07*
Relative mRNA expression of hippocampal IL-1β (AU)	1.0 ± 0	0.79 ± 0.09*†	0.74 ± 0.10*	0.68 ± 0.08*
Relative mRNA expression of hippocampal BDNF (AU)	1.0 ± 0	1.6 ± 0.1*	1.8 ± 0.4*	1.7 ± 0.5*
Relative mRNA expression of hippocampal CNTF (AU)	1.0 ± 0	2.1 ± 0.5*	2.9 ± 0.4*†	2.2 ± 0.7*
Relative mRNA expression of hippocampal Tau (AU)	1.0 ± 0	0.76 ± 0.08*†	0.67 ± 0.09*	0.66 ± 0.08*

Amyloid-β_(25–35) infused rats were fed a high-fat diet containing dextrin (the AD-CON group), water extract of Cassiae Semen (the AD-CS group) or water extract of Forsythiae Fructus (the AD-FF group) for 49 days. Amyloid-β_(35–25) infused rats were fed a high-fat diet containing dextrin (the CON group). MDA, malondialdehyde. In mRNA expression, the CT values of the AD-CON group were used as the reference group. TNF-α, tumour necrosis factor-α; IL-1β, interleukin-1β; BDNF, brain-derived neurotropic factor; CNTF, ciliary neurotrophic factor. Values represent means ± standard deviations (n = 6 for triglyceride and glycogen contents; n = 3 for mRNA expression).

*Significantly different from the AD-CON by Tukey test at p < 0.05.

^†Significantly different from the CON by Tukey test at p < 0.05.