Table 1. Changes in urinary metabolites before and after LEX ingestion; showing only those with significant differences.

Category	Component	Mean (Standard deviation)		p-value after FDR adjustment
		mmol/mol Creatinine
		PRE	POST
Yeast and Fungi	3-Oxoglutaric acid	0.06 (0.05)	0.00 (0.01)	0.029
	Tartaric acid	0.32 (0.18)	0.07 (0.10)	0.049
	Arabinose	48.25 (17.17)	17.00 (5.21)	0.016
	Tricarballylic acid	0.11 (0.08)	0.02 (0.05)	0.024
Bacteria	2-Hydroxyphenylacetic acid	0.33 (0.12)	0.23 (0.18)	0.037
	4-Hydroxyhippuric acid	6.79 (3.31)	1.94 (1.15)	0.044
Clostridia	4-Cresol	8.75 (7.37)	2.76 (3.22)	0.027
TCA Cycle	2-Oxoglutaric acid	9.30 (5.03)	5.68 (4.81)	0.005
	Aconitic acid	9.78 (1.35)	3.15 (2.10)	0.005
Mitochondrial Amino Acid	3-Methylglutaric acid	0.59 (0.31)	0.21 (0.15)	0.023
	3-Hydroxyglutaric acid	7.59 (4.65)	2.09 (1.62)	0.029
	3-Methylglutaconic acid	1.15 (0.38)	0.73 (0.42)	0.011
Neurotransmitter	Homovanillic acid	1.95 (0.43)	0.81 (0.28)	0.006
	Vanillylmandelic acid	1.41 (0.17)	0.75 (0.36)	0.006
	Quinolinic acid	1.58 (0.33)	0.58 (0.28)	<0.001
	Kynurenic acid	1.18 (0.25)	0.39 (0.25)	<0.001
Pyrimidine	Thymine	0.18 (0.05)	0.09 (0.07)	0.049
Ketone and Fatty Acid Oxidation	Methylsuccinic acid	1.13 (0.28)	0.50(0.23)	0.004
Vitamin	Pantothenic acid	1.51 (0.53)	0.49 (0.32)	0.012
	3-Hydroxy-3-methylglutaric acid	11.13 (2.54)	4.91 (2.30)	0.011
	Methylcitric acid	0.57 (0.18)	0.21 (0.10)	0.011
Detoxification	Pyroglutamic acid	21.25 (3.01)	13.14 (4.07)	0.011
	Orotic acid	0.31 (0.16)	0.14 (0.12)	0.024
	2-Hydroxyhippuric acid	0.78 (0.68)	0.21 (0.31)	0.044
Amino Acid	Phenylpyruvic acid	0.85 (0.25)	0.50 (0.43)	0.037
	4-Hydroxyphenyllactic acid	0.22 (0.08)	0.06 (0.03)	0.011
Mineral	Phosphoric acid	3.58 (0.84) *1	2.67 (1.01) *1	0.039

*1: mol/mol Creatinine