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. 2022 Jan 27;17(1):e0263166. doi: 10.1371/journal.pone.0263166

Table 1. Characteristics of the included studies.

Studys Disease Sample Size Mean Age±SD Sex (Male/Female) Experimental Group Control Group Treatment duration Outcome
E C E C E C Acupoints Method of acupuncture
Yang2011 Functional dyspepsia 30 30 37.6± 9.8 38.4 ±10.1 13/17 15/15 Zusanli, Neiguan EA Domperidone 2W SAS, SDS
Li2011 Irritable bowel syndrome 35 35 39.1±11.80 37.93±11.45 15/20 18/17 Tianshu, Zusanli, Shangjuxu, Sanyinjiao, Taichong, Baihui, Yintang EA Pinaverium bromide 4W SAS, SDS
Chen2012 Irritable bowel syndrome 30 34 40.5±8.75 41.9±10.01 11/19 14/20 Baihui, Shenting, Neiguan, Shenmen, Zhongwan, Tianshu, Qihai, Sanyinjiao, Taichong EA Bacillus licheniformis + Flupentixol and Melitracen Tablets 4W HAMA, HAMD
Peng2013 Irritable bowel syndrome 20 20 47.5±3.2 45.8±4.0 8/12 10/10 Zusanli, Tianshu EA Macrogol 4000 Powders + Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines Live 4W SAS, SDS
Zhong2013 Functional constipation 170 62 43.85±17.79 41.97±18.07 33/139 13/49 1: Tianshu, Dachangshu EA Mosapride 4W SAS, SDS
2: Quchi, Shangjuxu
3: Tianshu, Dachangshu, Quchi, Shangjuxu
Wu2013 Functional constipation 23 18 27.91±8.91 28.39±9.68 8/15 6/12 Quchi, Shangjuxu EA Mosapride 4W SAS, SDS
Xiong2014 Functional constipation 67 41 NR NR NR NR Quchi, Shangjuxu EA Mosapride 4W SAS, SDS
Zheng2014 Irritable bowel syndrome 261 87 41.25±16.99 42.29±18.3 138/118 52/34 1: Tianshu, Dachangshu EA Loperamide Hydrochloride 4W SAS, SDS
2: Quchi, Shangjuxu
3: Tianshu, Dachangshu, Quchi, Shangjuxu
Tian2014 Functional diarrhoea 37 16 39.77±15.44 39.27±16.88 NR NR Tianshu, Dachangshu EA Loperamide Hydrochloride 4W SAS, SDS
Da2014 Functional constipation 18 16 51.22±22.84 38.38±19.61 4/14 2/14 Tianshu, Fujie, Shangjuxu EA SA 8W SAS, SDS
Jin2015 Functional dyspepsia 28 28 49.29±10.32 48.25±11.40 11/17 10/18 Zusanli, Taixi, Zulinqi, Neiguan, Shenmen MA SA 4W SAS, SDS
Yuan2015 Functional dyspepsia 31 32 44.21±21.12 39.21±25.12 13/18 15/17 Gongsun, Neiguan MA Domperidone 4W HAMA, HAMD
Lian2016 Functional diarrhoea 32 30 33.85±12.55 31.60±11.56 14/18 11/19 Tianshu, Dachangshu, Quchi, Shangjuxu EA Loperamide Hydrochloride 4W SAS
Du2016 Functional dyspepsia 48 47 44.89±10.12 43.28±12.05 13/35 15/32 Shenque, Sishencong, Shenmen, Baihui, Zusanli, Zhongwan, Neiguan EA Domperidone 4W HAMD
Ding2016 Functional diarrhoea 48 19 43.19±17.08 41.37±16.74 28/17 8/11 Tianshu, Dachangshu 1: EA with strong stimulation Loperamide Hydrochloride 4W SAS, SDS
2: EA with little stimulation
Li2017 Irritable bowel syndrome 79 39 46.3±13.2 48.9±12.4 42/34 17/16 Baihui, Yintang, Tianshu, Zusanli, Shangjuxu, Sanyinjiao, Taichong MA Pinaverium bromide 6W SAS, SDS
Nie2017 Functional diarrhoea 53 53 46.4±10.8 46.1±10.6 29/24 32/21 Tianshu, Shangjuxu MA Loperamide Hydrochloride 4W SAS, SDS
Shen2018 Functional dyspepsia 32 32 45.71±11.26 44.21±11.59 7/27 6/28 Baihui, Yintang, Neiguan, Zhongwan, Tianshu, Qihai, Zusanli, Sanyinjiao, Taichong EA Mosapride 4W HAMA, HAMD
Zhong2018 Irritable bowel syndrome 60 30 31.12±12.74 30.22±13.99 35/25 21/9 1: Quchi, Shangjuxu EA Loperamide Hydrochloride 4W SAS, SDS
2: Quchi, Shangjuxu, Tianshu, Dachangshu
Mak2019 Irritable bowel syndrome 40 40 50.85±11.57 50.83±14.15 20/20 18/22 Neiguan, Shenmen, Zusanli, Shangjuxu, Sanyinjiao, Taichong, Baihui, Yintang EA SA 10W PHQ-9, GAD-7
Meng2019 Irritable bowel syndrome 35 35 39.3±11.5 38.4±13.5 16/19 13/22 Taichong, Zusanli, Shangjuxu, Sanyinjiao, Tianshu, Baihui, Yintang MA Pinaverium bromide 4W SDS
Chen2019 Functional dyspepsia 35 35 40.97±11.70 43.59±12.4 11/22 14/20 Zhongwan, Tianshu, Zusanli, Neiguan, Baihui, Taichong MA SA 4W SAS, SDS
Xu2020 Functional dyspepsia 31 33 35.3±19.1 35.4±15.3 6/25 6/27 Quchi, Shangjuxu EA 1: Mosapride 4W SAS, SDS
2:SA+Mosapride
Yang2020 Irritable bowel syndrome 20 20 55.0±5.4 54±6.1 12/8 10/10 Neiguan, Tianshu, Sanyinjiao, Zusanli, Shangjuxu, Taichong, Yintang MA Montmorillonite powder + Flupentixol and Melitracen Tablets 2W HAMA, HAMD

E: Experimental Group; C: Control Group; MA: Manual acupuncture; EA: Electroacupuncture; SA: Sham acupuncture; NR: Not report; SAS: Self-Rating Anxiety Scale; SDS: Self-Rating depression Scale; HAMA: Hamilton Rating Scale for Anxiety; HAMD: Hamilton Rating Scale for Depression; PHQ-9: Patient Health Questionnaire-9 items; GAD-7: Generalized Anxiety Disorder-7 item