Table 1. Characteristics of the included studies.
Studys | Disease | Sample Size | Mean Age±SD | Sex (Male/Female) | Experimental Group | Control Group | Treatment duration | Outcome | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
E | C | E | C | E | C | Acupoints | Method of acupuncture | |||||
Yang2011 | Functional dyspepsia | 30 | 30 | 37.6± 9.8 | 38.4 ±10.1 | 13/17 | 15/15 | Zusanli, Neiguan | EA | Domperidone | 2W | SAS, SDS |
Li2011 | Irritable bowel syndrome | 35 | 35 | 39.1±11.80 | 37.93±11.45 | 15/20 | 18/17 | Tianshu, Zusanli, Shangjuxu, Sanyinjiao, Taichong, Baihui, Yintang | EA | Pinaverium bromide | 4W | SAS, SDS |
Chen2012 | Irritable bowel syndrome | 30 | 34 | 40.5±8.75 | 41.9±10.01 | 11/19 | 14/20 | Baihui, Shenting, Neiguan, Shenmen, Zhongwan, Tianshu, Qihai, Sanyinjiao, Taichong | EA | Bacillus licheniformis + Flupentixol and Melitracen Tablets | 4W | HAMA, HAMD |
Peng2013 | Irritable bowel syndrome | 20 | 20 | 47.5±3.2 | 45.8±4.0 | 8/12 | 10/10 | Zusanli, Tianshu | EA | Macrogol 4000 Powders + Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines Live | 4W | SAS, SDS |
Zhong2013 | Functional constipation | 170 | 62 | 43.85±17.79 | 41.97±18.07 | 33/139 | 13/49 | 1: Tianshu, Dachangshu | EA | Mosapride | 4W | SAS, SDS |
2: Quchi, Shangjuxu | ||||||||||||
3: Tianshu, Dachangshu, Quchi, Shangjuxu | ||||||||||||
Wu2013 | Functional constipation | 23 | 18 | 27.91±8.91 | 28.39±9.68 | 8/15 | 6/12 | Quchi, Shangjuxu | EA | Mosapride | 4W | SAS, SDS |
Xiong2014 | Functional constipation | 67 | 41 | NR | NR | NR | NR | Quchi, Shangjuxu | EA | Mosapride | 4W | SAS, SDS |
Zheng2014 | Irritable bowel syndrome | 261 | 87 | 41.25±16.99 | 42.29±18.3 | 138/118 | 52/34 | 1: Tianshu, Dachangshu | EA | Loperamide Hydrochloride | 4W | SAS, SDS |
2: Quchi, Shangjuxu | ||||||||||||
3: Tianshu, Dachangshu, Quchi, Shangjuxu | ||||||||||||
Tian2014 | Functional diarrhoea | 37 | 16 | 39.77±15.44 | 39.27±16.88 | NR | NR | Tianshu, Dachangshu | EA | Loperamide Hydrochloride | 4W | SAS, SDS |
Da2014 | Functional constipation | 18 | 16 | 51.22±22.84 | 38.38±19.61 | 4/14 | 2/14 | Tianshu, Fujie, Shangjuxu | EA | SA | 8W | SAS, SDS |
Jin2015 | Functional dyspepsia | 28 | 28 | 49.29±10.32 | 48.25±11.40 | 11/17 | 10/18 | Zusanli, Taixi, Zulinqi, Neiguan, Shenmen | MA | SA | 4W | SAS, SDS |
Yuan2015 | Functional dyspepsia | 31 | 32 | 44.21±21.12 | 39.21±25.12 | 13/18 | 15/17 | Gongsun, Neiguan | MA | Domperidone | 4W | HAMA, HAMD |
Lian2016 | Functional diarrhoea | 32 | 30 | 33.85±12.55 | 31.60±11.56 | 14/18 | 11/19 | Tianshu, Dachangshu, Quchi, Shangjuxu | EA | Loperamide Hydrochloride | 4W | SAS |
Du2016 | Functional dyspepsia | 48 | 47 | 44.89±10.12 | 43.28±12.05 | 13/35 | 15/32 | Shenque, Sishencong, Shenmen, Baihui, Zusanli, Zhongwan, Neiguan | EA | Domperidone | 4W | HAMD |
Ding2016 | Functional diarrhoea | 48 | 19 | 43.19±17.08 | 41.37±16.74 | 28/17 | 8/11 | Tianshu, Dachangshu | 1: EA with strong stimulation | Loperamide Hydrochloride | 4W | SAS, SDS |
2: EA with little stimulation | ||||||||||||
Li2017 | Irritable bowel syndrome | 79 | 39 | 46.3±13.2 | 48.9±12.4 | 42/34 | 17/16 | Baihui, Yintang, Tianshu, Zusanli, Shangjuxu, Sanyinjiao, Taichong | MA | Pinaverium bromide | 6W | SAS, SDS |
Nie2017 | Functional diarrhoea | 53 | 53 | 46.4±10.8 | 46.1±10.6 | 29/24 | 32/21 | Tianshu, Shangjuxu | MA | Loperamide Hydrochloride | 4W | SAS, SDS |
Shen2018 | Functional dyspepsia | 32 | 32 | 45.71±11.26 | 44.21±11.59 | 7/27 | 6/28 | Baihui, Yintang, Neiguan, Zhongwan, Tianshu, Qihai, Zusanli, Sanyinjiao, Taichong | EA | Mosapride | 4W | HAMA, HAMD |
Zhong2018 | Irritable bowel syndrome | 60 | 30 | 31.12±12.74 | 30.22±13.99 | 35/25 | 21/9 | 1: Quchi, Shangjuxu | EA | Loperamide Hydrochloride | 4W | SAS, SDS |
2: Quchi, Shangjuxu, Tianshu, Dachangshu | ||||||||||||
Mak2019 | Irritable bowel syndrome | 40 | 40 | 50.85±11.57 | 50.83±14.15 | 20/20 | 18/22 | Neiguan, Shenmen, Zusanli, Shangjuxu, Sanyinjiao, Taichong, Baihui, Yintang | EA | SA | 10W | PHQ-9, GAD-7 |
Meng2019 | Irritable bowel syndrome | 35 | 35 | 39.3±11.5 | 38.4±13.5 | 16/19 | 13/22 | Taichong, Zusanli, Shangjuxu, Sanyinjiao, Tianshu, Baihui, Yintang | MA | Pinaverium bromide | 4W | SDS |
Chen2019 | Functional dyspepsia | 35 | 35 | 40.97±11.70 | 43.59±12.4 | 11/22 | 14/20 | Zhongwan, Tianshu, Zusanli, Neiguan, Baihui, Taichong | MA | SA | 4W | SAS, SDS |
Xu2020 | Functional dyspepsia | 31 | 33 | 35.3±19.1 | 35.4±15.3 | 6/25 | 6/27 | Quchi, Shangjuxu | EA | 1: Mosapride | 4W | SAS, SDS |
2:SA+Mosapride | ||||||||||||
Yang2020 | Irritable bowel syndrome | 20 | 20 | 55.0±5.4 | 54±6.1 | 12/8 | 10/10 | Neiguan, Tianshu, Sanyinjiao, Zusanli, Shangjuxu, Taichong, Yintang | MA | Montmorillonite powder + Flupentixol and Melitracen Tablets | 2W | HAMA, HAMD |
E: Experimental Group; C: Control Group; MA: Manual acupuncture; EA: Electroacupuncture; SA: Sham acupuncture; NR: Not report; SAS: Self-Rating Anxiety Scale; SDS: Self-Rating depression Scale; HAMA: Hamilton Rating Scale for Anxiety; HAMD: Hamilton Rating Scale for Depression; PHQ-9: Patient Health Questionnaire-9 items; GAD-7: Generalized Anxiety Disorder-7 item