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. 2022 Jan 27;17(1):e0261000. doi: 10.1371/journal.pone.0261000

Fig 2. Acute effect of Compound 1 on MBP and RBF in anesthetized CD rats.

Fig 2

Green arrow indicates start of IV infusion of Vehicle or Compound 1 for 30 minutes. (A) Black circle represents data from vehicle treated group; red triangle represents data from low dose of compound 1 at 0.05 mg/kg, the blue rectangle represents high dose of compound 1 at 0.1 mg/kg. Each data point represents the averaged data of MBP in a 10-min interval and shows dose-dependent effect of Compound 1 on the percentage change of MBP from baseline. In comparison with data from the Vehicle-treated group, Compound 1 significantly decreased MBP in both 0.05 and 0.1 mg/kg doses.(B) shows dose-dependent effect of Compound 1 on the percentage change of RBF. Only the high dose of Compound 1 significantly increased RBF vs Vehicle control. *P <0.05 **P <0.01, ***P <0.001, ****P <0.0001 vs Vehicle control. Two-way repeated measures ANOVA with multiple comparisons followed by Tukey test. C and D. Acute effect of Compound 1 and/or Enalaprilat on MBP and RBF in anesthetized ZSF1 OB rats.