Figure 1.

In vivo hemodynamic measurements in SuHx rats through the 10-wk time course of the study showed significant increases by week 3 in end-systolic (ES) right ventricular pressure (A) and total pulmonary vascular resistance (C), and significant increases by week 5 in end-diastolic (ED) pressure (B) and peak positive time derivative of right ventricular pressure (F). Although ES volume (D) increased significantly, ED volume (E) was preserved throughout the study apart from a small but significant increase at week 3, and stroke volume (G) was only significantly lower than control after week 6. Mean ejection fraction (H) decreased significantly by week 4 but did not change after week 4 (P > 0.05, comparison not shown). The magnitude of peak negative time derivative of pressure (I) increased significantly at week 3 and after week 4. Data are shown as means ± SE, *P < 0.05 and #P < 0.01 compared with the control group. SuHx, sugen-hypoxia.