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Inhalation of EPFRs for 3 days reduced lung tidal volume but had only a modest impact on lung function. Mice were exposed to either filtered air or 1.5 mg/m3 DCB230 for 4 h/day for 3 days. Tidal volumes were measured using whole body plethysmography (A) and inflammatory cell populations in the lungs and peripheral blood were determined using flow cytometry (B). *Significance compared with filtered air (lungs: n = 7 or 8/group; peripheral blood: n = 4–8/group).
