Table 4.
Viscosity classification accuracy (ACC) of the 20 mAbs in this study using the SCM score and the machine learning model from a previous work. Predicted and experimental high viscosity are shaded in gray. The high viscosity is defined as SCM_neg_Fv > 1000, 12< mAb_chg<32 and HVI>17.3, and Vis_exp > 30 cP, respectively. Correct predictions are labeled as 1, and wrong predictions are labeled as 0
| SCM_neg_Fv | mAb_chg | HVI | Vis_exp (150 mg/ml) | SCM_pred | ML_pred | ||
|---|---|---|---|---|---|---|---|
| mAb1 | 772.7 | 28 | 14.60 | 16.64 | 1 | 1 | |
| mAb2 | 1214.6 | 20 | 15.56 | 6.49 | 0 | 1 | |
| mAb3 | 869 | 28 | 17.02 | 7.30 | 1 | 1 | |
| mAb4 | 870 | 32 | 23.38 | 9.72 | 1 | 1 | |
| mAb5 | 1055 | 24 | 19.74 | 7.03 | 0 | 0 | |
| mAb6 | 507.6 | 28 | 14.98 | 10.41 | 1 | 1 | |
| mAb7 | 1010.2 | 26 | 16.09 | 23.33 | 0 | 1 | |
| mAb8 | 2156.2 | 4 | 12.45 | 16.07 | 0 | 1 | |
| mAb9 | 808.1 | 12 | 10.04 | 6.23 | 1 | 1 | |
| mAb10 | 667.5 | 24 | 16.74 | 227.54 | 0 | 0 | |
| mAb11 | 987.2 | 24 | 18.26 | 25.95 | 1 | 0 | |
| mAb12 | 767 | 30 | 13.79 | 108.25 | 0 | 0 | |
| mAb13 | 1089.1 | 22 | 20.18 | 93.00 | 1 | 1 | |
| mAb14 | 993.9 | 24 | 17.11 | 102.46 | 0 | 0 | |
| mAb15 | 993.6 | 26 | 20.6 | 21.26 | 1 | 0 | |
| mAb16 | 1151.8 | 18 | 16.45 | 115.60 | 1 | 0 | |
| mAb17 | 763 | 32 | 22.52 | 13.14 | 1 | 1 | |
| mAb18 | 886.9 | 24 | 12.72 | 13.63 | 1 | 1 | |
| mAb19 | 1294.7 | 26 | 22.47 | 7.80 | 0 | 0 | |
| mAb20 | 1292.7 | 20 | 16.59 | 48.86 | 1 | 0 | |
| ACC (%) | 60 | 55 |