Table 2.

Performance comparisons of pre-radiomics and delta-radiomics models in primary and validation cohorts in terms of ACC, sensitivity, specificity, PPV, NPV, OR, F1 score, F1 weighted score and MCC, respectively

Model		ACC (%)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	OR	F1 Score	F1-Weighted	MCC
Primary Dataset	preRadiomics Model	77.42	82.35	74.58	65.12	88.00	13.69	0.73	0.78	0.55
	∆Radiomics Model	78.49	61.76	88.14	75.00	80.00	12.00	0.68	0.78	0.52
	RECIST Model	72.04	35.29	93.22	75.00	71.43	7.50	0.48	0.69	0.36
Validation Dataset 1	preRadiomics Model	52.94	73.33	47.17	28.21	86.21	2.46	0.41	0.57	0.17
	∆Radiomics Model	76.47	66.67	79.25	47.62	89.36	7.64	0.56	0.78	0.41
	RECIST Model	76.47	20.00	92.45	42.86	80.33	3.06	0.27	0.73	0.17
Validation Dataset 2	preRadiomics Model	50.79	41.67	56.41	37.04	61.11	0.92	0.39	0.51	0.02
	∆Radiomics Model	80.95	79.17	82.05	73.08	86.49	17.37	0.76	0.81	0.60
	RECIST Model	80.95	66.67	89.74	80.00	81.40	17.50	0.73	0.81	0.59