Table 3.

Comparisons of pre- and delta-radiomics models for overall, ADC and SCC patients in validation cohort 1 and 2 by evaluating on metrics of ACC, sensitivity, specificity, PPV, NPV, OR, F1 score, F1 weighted score and MCC, respectively

Model			ACC (%)	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	OR	F1 Score	F1-Weighted	MCC
Validation Dataset 1	preRadiomics Model	Overall	52.94	73.33	47.17	28.21	86.21	2.46	0.41	0.57	0.17
		ADC	53.70	72.72	48.84	26.67	87.50	2.55	0.39	0.58	0.17
		SCC	50.00	75.00	40.00	33.33	80.00	2.00	0.46	0.51	0.14
	∆Radiomics Model	Overall	76.47	66.67	79.25	47.62	89.36	7.64	0.56	0.78	0.41
		ADC	77.78	72.73	79.07	47.06	91.89	10.07	0.57	0.79	0.45
		SCC	71.43	50.00	80.00	50.00	80.00	4.00	0.50	0.71	0.30
Validation Dataset 2	preRadiomics Model	Overall	50.79	41.67	56.41	37.04	61.11	0.92	0.39	0.51	−0.02
		ADC	55.26	46.67	60.87	43.75	63.64	1.36	0.45	0.55	0.07
		SCC	44.00	33.33	50.00	27.27	57.14	0.5	0.30	0.45	−0.16
	∆Radiomics Model	Overall	80.95	79.17	82.05	73.08	86.49	17.37	0.76	0.81	0.60
		ADC	89.47	86.67	91.30	86.67	0.91	68.25	0.87	0.89	0.78
		SCC	68.00	66.67	68.75	54.55	78.57	4.4	0.60	0.69	0.34