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. 2020 Jun 30;4:12. doi: 10.21037/med-20-31

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2020 Mediastinum. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.

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HS. (A) Syncytial sheets of markedly atypical cells with eosinophilic cytoplasm, prominent nucleoli, and mitotic activity (H&E stain, 400× magnification); (B) diffuse CD163 reactivity (immunohistochemistry, 400× magnification); (C) separate case showing sheets of tumor cells with marked nuclear pleomorphism, foamy cytoplasm, and scattered admixed non-neoplastic inflammatory cells (H&E stain, 400× magnification). The morphology of histiocytic sarcoma is not specific and would be compatible with other pleomorphic tumors given a different immunoprofile. Thus, diagnosis of HS requires a broad panel of immunohistochemical stains to exclude other tumors. HS, histiocytic sarcoma.