. Author manuscript; available in PMC: 2022 Jan 27.

Published in final edited form as: Emerg Contam. 2021 Oct 31;7:219–235. doi: 10.1016/j.emcon.2021.10.004

Table 2.

Serum glucose and insulin of fasted offspring at Week 18.

		Treatment	Glucose (mg/dL)	Insulin (pg/mL)	QUICKI
Female	LFD	Vehicle	167.8 ± 28.0	602.8 ± 374.1	0.760 ± 0.170
		GenX 0.2 mg/kg	159.9 ± 18.7	686.9 ± 598.6	0.741 ± 0.139
		GenX 1.0 mg/kg	162.0 ± 27.1	543.0 ± 383.7	0.790 ± 0.176
		GenX 2.0 mg/kg	158.4 ± 56.0	373.9 ± 271.8	1.174 ± 0.850
		PFOA 0.1 mg/kg	180.4 ± 14.9	411.1 ± 307.5	0.910 ± 0.300
		PFOA 1.0 mg/kg	155.3 ± 19.1	701.8 ± 846.9	0.857 ± 0.279
	HFD	Vehicle	188.0 ± 19.0	1539.3 ± 1067.1	0.573 ± 0.127
		GenX 0.2 mg/kg	153.1 ± 16.9	903.0 ± 619.1	0.676 ± 0.128
		GenX 1.0 mg/kg	183.0 ± 22.3	2876.7 ± 2614.2	0.547 ± 0.165
		GenX 2.0 mg/kg	172.8 ± 36.4	829.8 ± 581.0	0.713 ± 0.231
		PFOA 0.1 mg/kg	165.6 ± 17.1	653.0 ± 689.9	0.808 ± 0.229
		PFOA 1.0 mg/kg	203.1 ± 50.4	6162.4 ± 7279.9 ^*	0.577 ± 0.315
Male	LFD	Vehicle	179.7 ± 26.5	933.5 ± 791.3	0.802 ± 0.473
		GenX 0.2 mg/kg	190.4 ± 32.3	1043.9 ± 515.6^†	0.600 ± 0.094
		GenX 1.0 mg/kg	192.4 ± 31.1	2506.5 ± 1588.8^†	0.530 ± 0.187
		GenX 2.0 mg/kg	181.0 ± 22.9	6597.5 ± 8869.8^*,^†	0.463 ± 0.103 ^*
		PFOA 0.1 mg/kg	190.0 ± 29.3	2048.4 ± 1301.0^†	0.587 ± 0.281
		PFOA 1.0 mg/kg	250.2 ± 199.0	4271.2 ± 3391.1^†	0.456 ± 0.114 ^*
	HFD	Vehicle	255.6 ± 113.6	4775.8 ± 1899.4	0.407 ± 0.044
		GenX 0.2 mg/kg	251.0 ± 137.8	7282.4 ± 7409.6	0.407 ± 0.078
		GenX 1.0 mg/kg	252.6 ± 118.0	20027.8 ± 18986.2 ^*	0.354 ± 0.074
		GenX 2.0 mg/kg	196.2 ± 46.1	6135.3 ± 4838.6	0.423 ± 0.063
		PFOA 0.1 mg/kg	208.4 ± 93.4	4452.9 ± 3456.6	0.444 ± 0.064
		PFOA 1.0 mg/kg	198.1 ± 36.6	4954.8 ± 2416.4	0.421 ± 0.045

Note: Data presented as mean ± SD, N = 7–11.

P < 0.05 relative to vehicle control (one-way ANOVA, Dunnett’s post hoc test) within diet.

^†

P < 0.001, Jonckheere’s trend test for a dose response across the GenX or PFOA doses.

Abbr: QUICKI = Quantitative Insulin Sensitivity Check Index.