Figure 2.

Cardiac fibrosis and inflammation in mice

Mice were injected with STZ to establish the DCM model and then treated with CWA (2 mg/kg and 8 mg/kg) from 12 to 16 weeks after the final STZ injection. a and b. Representative image of picrosirius red (PSR) staining and quantification results of collagen volume in the mouse hearts in the indicated groups (n = 6). c-e. Transcription (C) and protein levels (d, e) of fibrosis markers (n = 6). *P < 0.05 vs. vehicle/sham; #P < 0.05 vs. vehicle/STZ.