Table 4.
PFT and HRCT findings at follow-up in relevant interstitial lung sequelae (RILS) groups categorized by the Warrick score.
| Non-RILS group (n = 198) | RILS group (n = 154) | Total (N = 352) | *P-value | |
|---|---|---|---|---|
| PFT | ||||
| FVC <80% pred., N (%) | 25 (12.6) | 54 (35.1) | 79 (22.4) | <0.001 |
| FEV1 <80% pred., N (%) | 28 (14.1) | 47 (30.5) | 75 (21.3) | <0.001 |
| DLCO <80% pred., N (%) | 102 (51.5) | 132 (85.7) | 234 (66.5) | <0.001 |
| FVC% pred., mean (SD) | 96.5 (16.7) | 88.3 (19.6) | 92.9 (18.4) | <0.001 |
| FEV1% pred., mean (SD) | 102.6 (66.0) | 91.0 (20.9) | 97.5 (51.8) | <0.001 |
| DLCO% pred., mean (SD) | 80.6 (16.9) | 60.9 (17.5) | 72.3 (19.7) | <0.001 |
| HRCT, N(%) | ||||
| Ground glass opacities | 92 (46.5) | 152 (98.7) | 244 (69.3) | <0.001 |
| Consolidations | 3 (1.5) | 30 (19.5) | 33 (9.4) | <0.001 |
| Irregular pleura | 7 (3.5) | 81 (52.6) | 88 (25.0) | <0.001 |
| Septal/subpleural lines | 76 (38.4) | 153 (99.4) | 229 (65.1) | <0.001 |
| Subpleural cysts | 0 (0) | 18 (11.7) | 18 (5.1) | <0.001 |
| Honeycomb | 0 (0) | 4 (2.6) | 4 (1.1) | 0.036 |
| Architecture distortion | 0 (0) | 47 (30.5) | 47 (13.4) | <0.001 |
| Traction bronchiectasis | 0 (0) | 26 (16.9) | 26 (7.4) | <0.001 |
| Atelectasis | 7 (3.5) | 20 (13) | 27 (7.7) | 0.001 |
| Nodules | 10 (5.1) | 18 (11.7) | 28 (8.0) | 0.022 |
| Pleural effusion | 0 (0) | 4 (2.6) | 4 (1.1) | 0.036 |
| Hypoattenuation | 24 (12.1) | 64 (41.6) | 88 (25.0) | <0.001 |
*
P-value comparisons between non-RILS and RILS groups.
RILS, relevant interstitial lung sequelae defined as a Warrick score ≥ 7; DLCO, lung diffusing capacity for carbon monoxide; FEV1, forced expiratory volume in the first second; FVC, forced vital capacity; HRCT, high-resolution computed tomography; IQR, interquartile range; PFT, pulmonary function test; RILS, relevant interstitial lung sequelae.