Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Half-maximal inhibitory concentration (EC50) against P. falciparum sensitive and resistance strains, resistance index (RI = EC50resistant/ EC503D7)
| Compound | EC50 (µM) average ± SD | ||||||
|---|---|---|---|---|---|---|---|
| 3D7 | Dd2 | RI | TM90C6B | RI | 3D7R_848 | RI | |
| 11 | 8 ± 4 | 30 ± 20 | 3.8 | 31 ± 8 | 3.9 | 7 ± 3 | 0.9 |
| Artesunate | 0.008 ± 0.002 | 0.007 ± 0.003 | 0.9 | 0.0069 ± 0.0006 | 0.9 | 0.012 ± 0.006 | 1.5 |
| Pyrimethamine | 0.045 ± 0.004 | >10 | >222 | – | – | – | – |
| Atovaquone | 0.0008 ± 0.0002 | – | – | >1 | >1250 | – | – |
| MMV692848 | 0.12 ± 0.02 | – | – | – | – | 2.4 ± 0.3 | 20 |
