Skip to main content
. 2022 Jan 28;33(2):571–600. doi: 10.1007/s11224-021-01871-2

Table 2.

List of deketene curcumin and its derivatives utilized for docking study with aromatase and Erα+

Ligand no Compound 2D Structure and 3D Structure Active against Reference
DKC-1 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadiene-3-one graphic file with name 11224_2021_1871_Figa_HTML.gif

B78H1 melanoma

Cells, human colorectal carcinoma cells

 [31, 41]
DKC-2 1,5-bis(4-hydroxy-3-methoxyphenyl)pent-1,4-dien-3-ylidenmalononitrile graphic file with name 11224_2021_1871_Figb_HTML.gif human tumor cell lines as lung carcinoma NCI-460, melanoma UACC-62, breast MCF-7, colon HT-29, renal 786-O, ovarian OVCAR-03 and ovarian expressing [33]
DKC-3 1,5-bis(4-hydroxy-3-methoxyphenyl)pent-1,4-dien-3-ylidenmalononitrile graphic file with name 11224_2021_1871_Figc_HTML.gif human tumor cell lines as lung carcinoma NCI-460, melanoma UACC-62, breast MCF-7, colon HT-29, renal 786-O, ovarian OVCAR-03 and ovarian expressing [32]
DKC-4 (1E,4E)-1,5-bis(4-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figd_HTML.gif Active against HL-60 cell line [32]
DKC-5 (1E,4E)-1,5-bis(4-hydroxy-3,5-dimethoxyphenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Fige_HTML.gif human colorectal cancer cell lines, Antioxident [31, 42]
DKC-6 ((1E,4E)-3-oxopenta-1,4-diene-1,5-diyl)bis(2-methoxy-4,1-phenylene) bis(sulfamate) graphic file with name 11224_2021_1871_Figf_HTML.gif growth inhibitory activities on both prostate and breast cancer lines [43]
DKC-7 ((1E,4E)-3-oxopenta-1,4-diene-1,5-diyl)bis(2,6-dimethoxy-4,1-phenylene) bis(sulfamate) graphic file with name 11224_2021_1871_Figg_HTML.gif growth inhibitory activities on both prostate and breast cancer lines [43]
DKC-8 (1E,4E)-1,5-bis(3,5-bis(methoxymethoxy)phenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figh_HTML.gif Cell growth inhibition against HCT116 [44]
DKC-9 (1E,4E)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figi_HTML.gif inhibit the HIV-1 IN in enzyme assays, Antioxidant [42, 45]
DKC-10 N-(10-((1-((2,6-dimethoxy-4-((1E,4E)-3-oxo-5-(3,4,5-trimethoxyphenyl)penta-1,4-dien-1-yl)phenoxy)methyl)-1H-1,2,3-triazol-4-yl)methoxy)decyl)-4-((3aS,5S,6aR)-2-oxohexahydro-1H-thieno[2,3-d]imidazol-5-yl)butanamide graphic file with name 11224_2021_1871_Figj_HTML.gif Cell growth inhibition against HCT116 [44]
DKC-11 (1E,4E)-1,5-bis(3,5-bis(2-methoxyethoxy)phenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figk_HTML.gif Cell growth inhibition against HCT116 [44]
DKC-12 (1E,4E)-1,5-bis(3,5-bis(2-hydroxyethoxy)phenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figl_HTML.gif Cell growth inhibition against HCT116 [44]
DKC-13 (1E,4E)-1,5-bis(3,5-bis((2-methoxyethoxy)methoxy)phenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figm_HTML.gif Cell growth inhibition against HCT116 [44]
DKC-14 (1E,4E)-1-(Benzo[d][1,3]dioxol-5-yl)-5-(3,5-bis(methoxymethoxy)phenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Fign_HTML.gif Cell growth inhibition against HCT116 [44]
DKC-15 (E)-ethyl 2-cyano-5-(4-hydroxy-3-methoxyphenyl)-3-((E)-4-hydroxy-3-methoxystyryl)penta-2,4-dienoate graphic file with name 11224_2021_1871_Figo_HTML.gif Lung tumor, Melanoma, Normal mamma tumor, (Mamma tumor which expresses the phenotype resistance against multiple drugs), Colon tumor, Renal tumor, Ovary tumor, Prostate tumor, Leukemia [46]
DKC-16 (1E,4E)-1,5-bis(4-hydroxy-3-methoxy-5-(3-methylbut-2-en-1-yl)phenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figp_HTML.gif Against various tumor: Lung tumor, Melanoma, Normal mamma tumor, Colon tumor, Renal tumor, Ovary tumor, Prostate tumor, Leukemia [46]
DKC-17 (E)-ethyl 2-cyano-5-(4-hydroxy-3-methoxyphenyl)-3-((E)-4-hydroxy-3-methoxystyryl)penta-2,4-dienoate graphic file with name 11224_2021_1871_Figq_HTML.gif Against various tumor: Lung tumor, Melanoma, Normal mamma tumor, Colon tumor, Renal tumor, Ovary tumor, Prostate tumor, Leukemia [46]
DKC-18 (1E,4E)-1,5-bis(3,4-dihydroxyphenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figr_HTML.gif Against various tumor: Lung tumor, Melanoma, Normal mamma tumor, Colon tumor, Renal tumor, Ovary tumor, Prostate tumor, Leukemia [46]
DKC-19 (1E,4E)-1,5-bis(3-bromo-5-methoxy-4-((3-methylbut-2-en-1-yl)oxy)phenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figs_HTML.gif Against various tumor: Lung tumor, Melanoma, Normal mamma tumor, Colon tumor, Renal tumor, Ovary tumor, Prostate tumor, Leukemia [46]
DKC-20 (1E,4E)-1-(4,5-dihydroxy-2,3-bis(3-methylbut-2-en-1-yl)phenyl)-5-(4,5-dihydroxy-3-(3-methylbut-2-en-1-yl)-2-(4-methylpent-3-en-1-yl)phenyl)penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figt_HTML.gif Against various tumor: Lung tumor, Melanoma, Normal mamma tumor, Colon tumor, Renal tumor, Ovary tumor, Prostate tumor, Leukemia [46]
DKC-21 1,5-Bis-(4-hydroxy-3-methoxy-5-morpholin-4-ylmethylphenyl)-penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figu_HTML.gif against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells [47]
DKC-22 1,5-Bis-(4-hydroxy-3-methoxy-5-pyrrolidin-1-ylmethylphenyl)-penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figv_HTML.gif against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells [47]
DKC-23 1,5-Bis-[4-hydroxy-3-methoxy-5-(4-methyl-piperazin-1-ylmethyl)-phenyl]-penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figw_HTML.gif against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells [47]
DKC-24 1,5-Bis-(3-diethylaminomethyl-4-hydroxy-5-methoxyphenyl)-penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figx_HTML.gif against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells [47]
DKC-25 1,5-Bis-(4-hydroxy-3-methoxy-5-piperidin-1-ylmethylphenyl)-penta-1,4-dien-3-one graphic file with name 11224_2021_1871_Figy_HTML.gif against HL-60 neoplasms and HSC-2, HSC-3 and HSC-4 carcinoma cells [47]