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. 2022 Jan 20;2022:6603296. doi: 10.1155/2022/6603296

Figure 3.

Figure 3

Glycosylation site mutations mitigated the prohypertrophic effects of CD147. (a) Representative images of the hearts and HE staining of four-chamber view sections. (b) Representative images of CMR examinations, HE staining, and WGA staining of heart sections from the indicated groups. (c) Statistical results for HW/BW, HW/TL, LW/TL, and myocyte cross-sectional areas for the indicated groups (n = 6–8 mice/group). (d) Western blot analysis of ANP and β-MHC in murine hearts from the indicated groups 8 weeks after transverse aortic constriction (TAC) surgery (n = 6 mice/group). Upper panel, representative blots. Lower panel, quantitative results. (e) mRNA levels of Anp, Bnp, α-Mhc, and β-Mhc in the indicated groups (n = 6 mice/group). Results were normalised to Gapdh levels and converted to fold induction relative to the sham group. ∗P < 0.05 vs. the sham group; ∗∗P < 0.01 vs. the sham group; ∗∗∗P < 0.001 vs. the sham group; ∗∗∗∗P < 0.0001 vs. the sham group; #P < 0.05 vs. the vehicle group; ##P < 0.01 vs. the vehicle group; ###P < 0.001 vs. the vehicle group; ✟P < 0.05 vs. the OE group; ✟✟P < 0.01 vs. the OE group; ✟✟✟P < 0.001 vs. the OE group. CMR: cardiovascular magnetic resonance; HE: haematoxylin-eosin; WGA: wheat germ agglutinin; HW: heart weight; BW: body weight; LW: lung weight; TL: tibia length; ANP: atrial natriuretic peptide; BNP: brain natriuretic peptide; β-MHC: myosin heavy chain β; α-MHC: myosin heavy chain α.