Table 1.
Demographics, health-related behaviors, physical measures, plasma lipids, and drug use in centenarian families.
| Centenarian n = 253 | Centenarian offspring n = 217 | Offspring spouses n = 116 | p value | |
|---|---|---|---|---|
| Demographics | ||||
| Age | 100.0 (99.0–101.0)# | 70.0 (65.0–75.0)∗ | 69.0 (64.5–74.0) | <0.001 |
| Male, n (%) | 66 (26.1%) | 153 (70.5%)#∗ | 29 (25.0%) | <0.001 |
| Smoking status | ||||
| Current smoker, n (%) | 12 (4.8%) | 54 (25.1%)#∗ | 12 (10.4%) | <0.001 |
| Former smoker, n (%) | 39 (15.6%)# | 41 (19.1%)# | 6 (5.2%) | 0.003 |
| Alcohol drinking status | ||||
| Current drinker, n (%) | 64 (25.7%) | 104 (48.6%)#∗ | 32 (28.1%) | <0.001 |
| Former drinker, n (%) | 36 (14.5%)# | 16 (7.5%) | 6 (5.3%) | 0.007 |
| Physical measures | ||||
| Waist circumference (cm) | 84.0 (76.0–90.0)# | 87.0 (80.0–93.0)∗ | 88.0 (81.0–97.0) | 0.001 |
| BMI (kg/m2) | 21.12 (18.79–23.73)# | 24.25 (22.29–26.58)∗ | 24.90 (22.26–27.75) | <0.001 |
| SBP (mmHg) | 150 (132–169)# | 141 (126–157)∗ | 140 (124–159) | <0.001 |
| DBP (mmHg) | 72 (64–82)# | 80 (73–87)∗ | 77 (71–85) | <0.001 |
| Lipids | ||||
| TC (mmol/L) | 4.6 (4.1–5.3)# | 5.1 (4.5–5.8)∗ | 5.2 (4.5–5.8) | <0.001 |
| LDL-C (mmol/L) | 2.89 (2.47–3.35)# | 3.26 (2.77–3.78)∗ | 3.34 (2.85–3.84) | <0.001 |
| HDL-C (mmol/L) | 1.32 (1.09–1.53) | 1.36 (1.20–1.60)∗ | 1.36 (1.13–1.55) | 0.049 |
| TG (mmol/L) | 1.02 (0.85–1.37)# | 1.15 (0.86–1.63)∗ | 1.24 (0.87–1.87) | 0.002 |
| Drug use | ||||
| Hypotensive therapy, n (%) | 48 (19.0%)# | 66 (30.4%)∗ | 44 (37.9%) | <0.001 |
| Lipid-lowering therapy, n (%) | 0 (0.0%) | 8 (3.7%)∗ | 1 (0.9%) | 0.002 |
n, number; %, percentage; BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides. #Bonferroni-corrected p < 0.05 versus offspring spouses. ∗Bonferroni-corrected p < 0.05 versus centenarians.