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. 2022 Jan 20;2022:2522249. doi: 10.1155/2022/2522249

Figure 2.

Figure 2

Effects of si-circ-ADAM9 on HG-induced ARPE-19 cell injury. ARPE-19 cells were transfected with si-NC or si-circ-ADAM9 and then treated with HG. The cells treated with NG were used as control. (a) The expression of circ-ADAM9 was measured by qRT-PCR. (b) ELISA was utilized to detect the concentrations of IL-6 and TNF-α. MTT assay (c), EdU assay (d), and flow cytometry (e) were determined to measure cell proliferation and apoptosis. (f) The protein expression of Bax and cleaved-caspase-3 was detected by the WB analysis. (g, h) MDA level and SOD activity were examined to assess cell oxidative stress. ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001.