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. 2022 Jan 20;2022:2522249. doi: 10.1155/2022/2522249

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Copyright © 2022 Zeyu Liang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Effects of si-CARM1 on HG-induced ARPE-19 cell injury. ARPE-19 cells were transfected with si-con or si-CARM1 and then treated with HG. The cells treated with NG were used as control. (a) The protein expression of CARM1 was detected by the WB analysis. (b) ELISA was used to analyze the concentrations of IL-6 and TNF-α. Cell proliferation and apoptosis were determined using MTT assay (c), EdU assay (d), and flow cytometry (e). (f) The WB analysis was performed to examine the protein expression of Bax and cleaved-caspase-3. (g, h) Cell oxidative stress was analyzed by detecting MDA level and SOD activity. ^∗∗P < 0.01, ^∗∗∗P < 0.001, and ^∗∗∗∗P < 0.0001.