Table 1.
The relationship between inflammasome SNPs and RA.
| SNP | Study population | Association | Ref. | |
|---|---|---|---|---|
| NLRP3 | rs10159239 | Caucasian | associated with RA susceptibility and anti-TNF response | (97) |
| rs4612666 | Denmark | associated with anti-TNF response | (98) | |
| rs10754558 | Denmark | associated with anti-TNF response | (99) | |
| rs10754558 | Brazil | associated with RA susceptibility and severity | (100) | |
| rs35829419 | Sweden | not associated with an increased susceptibility | (101) | |
| rs35829419 | Sweden | associated with an increased risk of stroke/transient ischemic attack | (102) | |
| rs35829419 | France, Tunisia | not associated with an increased susceptibility | (103) | |
| CARD8 | rs16981845 | Caucasian | associated with RA susceptibility and anti-TNF response | (97) |
| rs2043211 | Brazil | associated with RA susceptibility and severity | (100) | |
| rs2043211 | Sweden | associated with a worse disease course in early RA | (101) | |
| rs2043211 | Sweden | not associated with any type of CV event | (102) | |
| rs2043211 | Sweden | associated with RA susceptibility and severity | (104) | |
| rs2043211 | France, Tunisia | not associated with an increased susceptibility | (103) | |
| rs2043211 | Spain | not associated with RA susceptibility and the development of CV disease | (105) | |
| NLRP1 | rs878329G | Han Chinese | Increase risk of RA | (106) |
| rs6502867 T/C | Chinese Singaporean | not associated with risk of RA | (107) | |
| rs6502867 C/T | Chinese | not associated with risk of RA | (108) | |
| rs878329 C/G |
SNP, single nucleotide polymorphisms; CV, cardiovascular.