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. 2022 Jan 13;9:819785. doi: 10.3389/fcell.2021.819785

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Copyright © 2022 Lu, Xiao, Xu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of LINC00346 in glioma. LINC00346 upregulates SZRD1 levels by sponging miR-128-3p in glioma. LINC00346 modulates cell proliferation and apoptosis by regulating miR-128-3p/SZRD1. LINC00346 also functions as a ceRNA of miR-340-5p to reduce the expression level of ROCK1 in glioma. The expression level of LINC00346 is positively regulated by ankyrin repeat and KH domain-containing protein 1 (ANKHD1). Angiogenesis associated with glioma-associated endothelial cells (GECs) is facilitated by the ANKHD1/LINC00346/znf655 pathway.