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. 2022 Jan 13;12:805222. doi: 10.3389/fphar.2021.805222

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Copyright © 2022 Wang, Li, Zhao, Liu, Wang, Xiong and Mei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paeonol alleviated AEW-induced scratching behavior of dry skin mice. (A) The chemical structure of paeonol. (B) Schematic diagram of the animal experimental protocol. Spontaneous scratching of mice was videotaped and analysed. (C) The behavior results of different groups on day 7. Data were expressed as mean ± SEM. ^### p < 0.001, compared with the blank group. ^** p < 0.01, ^*** p < 0.001, compared with the AEW model (n = 6–7 each group). Pae-H, paeonol-high dose; Pae-M, paeonol-middle dose; Pae-L, paeonol-low dose; PC, positive control drug, HC-030031. The relevant labels in the following figures are the same unless otherwise mentioned.