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. 2022 Jan 13;12:805222. doi: 10.3389/fphar.2021.805222

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Copyright © 2022 Wang, Li, Zhao, Liu, Wang, Xiong and Mei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paeonol improved the pathological changes of dorsal neck skin in AEW mice. (A) The representative images of dorsal neck skin of each group on day 7. (B) The representative images of Haematoxylin and eosin (H&E) staining and the thickness of epidermis were measured. (C) The representative images of toluidine blue staining and the mast cell number were counted. Data were expressed as mean ± SEM. ^### p < 0.001, compared with the blank group; ^** p < 0.01, ^*** p < 0.001, compared with the AEW model group (n = 3 each group).