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. 2022 Jan 13;12:805222. doi: 10.3389/fphar.2021.805222

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Copyright © 2022 Wang, Li, Zhao, Liu, Wang, Xiong and Mei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of paeonol on chronic itch in AMG487 pre-treated WT and Cxcr3 ^−/− mice. (A) Schematic protocol of CXCR3 inhibition and induction of AEW-induced dry skin model. (B) Schematic protocol of AEW-induced dry skin model in Cxcr3 ^−/− mice. (C) The effects of paeonol on AEW-induced spontaneous scratching in WT mice pre-treated with AMG487. (D) The effects of paeonol on AEW-induced spontaneous scratching in Cxcr3 ^−/− mice (n = 7–9 each group). Data were expressed as mean ± SEM. ^∗∗ p < 0.01, ^∗∗∗ p < 0.001, compared to the WT-AEW model group.